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Multiple Pathways Involved in Palmitic Acid-Induced Toxicity: A System Biology Approach.
Inflammation is a complex biological response to injury, metabolic disorders or infections. In the brain, astrocytes play a vital role in the inflammatory process during neurodegenerative diseases. Recent studies have shown that increased saturated fatty acid free as palmitic acid metabolism produces an inflammatory response in astrocytes commonly associated with destructive mechanisms such as oxidative … Read more
Mechanistically detailed systems biology modeling of the HGF/Met pathway in hepatocellular carcinoma.
Hepatocyte progress issue (HGF) signaling by way of its receptor Met has been implicated in hepatocellular carcinoma tumorigenesis and development. Met interplay with integrins is proven to modulate the downstream signaling to Akt and ERK (extracellular-regulated kinase). In this examine, we developed a mechanistically detailed systems biology mannequin of HGF/Met signaling pathway that integrated particular … Read more
Using the Systems Biology Approach and Molecular Method to Investigate the Role of the Dopaminergic Pathway in Osteoarthritis: A Case Control Study.
Osteoarthritis is the most typical sort of arthritis and one of the main causes of job loss and motor disabilities. Recently, the involvement of dopaminergic pathways and dopamine receptor genes has been thought of in this illness. Therefore, finding out and evaluating the expression sample of these receptor genes can lead to a better understanding … Read more