Introducing Potential Key Proteins and Pathways in Human Laryngeal Cancer: A System Biology Approach.

The most common malignant neoplasms of the head and neck is laryngeal cancer which presents a significant international health issue.

The purpose of this study to screen potential protein associated with cancer of the larynx with network analysis for further understanding disease pathogenesis and biomarker discovery. differently expressed proteins were extracted from the literature that compare laryngeal cancer patient tissue proteome profiling> s with healthy controls.

PPI network were analyzed for up and down proteins regulated by Cytoscape Version 3.4. After construction of the PPI, topological properties of the two networks has been analyzed. In addition, by using MCODE. Gene Ontology (GO) analysis, related modules and pathways examined. Our study screened 275 proteins differentially change, including 136 up and 139 down-regulated proteins. For each network, has been regarded as the hub of key proteins 20 and 20 as an obstacle.

A total of 26 nodes hub-barriers are introduced to two networks. A total of 11 modules including 6 downregulated and upregulated network module 5 is obtained. GO most significant function within the module is significantly upregulated RNA processing, and most significantly downregulated in the module with the highest score is the respiratory electron transport chain. Among 275 investigated protein, 12 essential proteins determined that 4 of them can be introduced as a biomarker panel that may include YWHAZ, PPP2R1A, HSP90AA1, and CALM3 for human laryngeal cancer.

Ultraviolet wavelength-sensitive opsin Polyclonal Antibody

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EUR 415

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Orion AQUAfast IV Colorimeter 4 wavelengths and auto ID - EACH

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Description: A fluorescent probe, commonly used to stain DNA and chromosomes

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DAPI staining kit (ready to use) 

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EUR 150

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EUR 260

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EUR 398

Annexin V-ER780/DAPI Apoptosis Kit

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EUR 75

Annexin V-ER780/DAPI Apoptosis Kit

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EUR 150

Anti-Fade Mounting Medium (With DAPI)

abx090690-10ml 10 ml
EUR 243.6

DAPI blue fluorescent nuclear DNA dye

6244 10 mg
EUR 120.5

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abx090690-100l 100 µl
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Anti-fade Mounting Medium (With DAPI)

MBS355738-10mL 10mL
EUR 180

Anti-fade Mounting Medium (With DAPI)

MBS355738-5x10mL 5x10mL
EUR 515

DAPI blue fluorescent nuclear DNA dye

MBS258073-10mg 10mg
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DAPI blue fluorescent nuclear DNA dye

MBS258073-5x10mg 5x10mg
EUR 930

EverBrite™ Mounting Medium with DAPI

23002-1 EA
EUR 172

Annexin V-Cyanine5/DAPI Apoptosis Kit

E-CK-A262-100Assays 100 Assays
EUR 260

Annexin V-Cyanine5/DAPI Apoptosis Kit

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EUR 398

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E-CK-A262-20Assays 20 Assays
EUR 75