Introducing Potential Key Proteins and Pathways in Human Laryngeal Cancer: A System Biology Approach.

The most common malignant neoplasms of the head and neck is laryngeal cancer which presents a significant international health issue.

The purpose of this study to screen potential protein associated with cancer of the larynx with network analysis for further understanding disease pathogenesis and biomarker discovery. differently expressed proteins were extracted from the literature that compare laryngeal cancer patient tissue proteome profiling> s with healthy controls.

PPI network were analyzed for up and down proteins regulated by Cytoscape Version 3.4. After construction of the PPI, topological properties of the two networks has been analyzed. In addition, by using MCODE. Gene Ontology (GO) analysis, related modules and pathways examined. Our study screened 275 proteins differentially change, including 136 up and 139 down-regulated proteins. For each network, has been regarded as the hub of key proteins 20 and 20 as an obstacle.

A total of 26 nodes hub-barriers are introduced to two networks. A total of 11 modules including 6 downregulated and upregulated network module 5 is obtained. GO most significant function within the module is significantly upregulated RNA processing, and most significantly downregulated in the module with the highest score is the respiratory electron transport chain. Among 275 investigated protein, 12 essential proteins determined that 4 of them can be introduced as a biomarker panel that may include YWHAZ, PPP2R1A, HSP90AA1, and CALM3 for human laryngeal cancer.

Orion AQUAfast Colorimeter 6 wavelengths for COD and other digestion methods
AQ3700	Scientific Laboratory Supplies	EACH	EUR 2109.6

DAPI
B1098-25	Biovision	each	EUR 496.8

DAPI
B1098-5	Biovision	each	EUR 170.4

DAPI
abx082063-10mg	Abbexa	10 mg	EUR 276

DAPI
40011-1	Biotium	EA	EUR 122

DAPI
BMD0063-100mg	Abbkine	100 mg	EUR 849
Description: DAPI is a popular blue fluorescent DNA dye.

DAPI
BMD0063-10mg	Abbkine	10 mg	EUR 119
Description: DAPI is a popular blue fluorescent DNA dye.

DAPI Dilactate
17509	AAT Bioquest	25 mg	EUR 109

DAPI Dilactate
17509-25mg	AAT Bioquest	25 mg	EUR 109
Description: DAPI is a fluorescent stain that binds strongly to DNA.

DAPI (hydrochloride)
C3362-10	ApexBio	10 mg	EUR 146.4

DAPI (hydrochloride)
C3362-25	ApexBio	25 mg	EUR 240

DAPI (hydrochloride)
C3362-5	ApexBio	5 mg	EUR 111.6

DAPI (dihydrochloride)
HY-D0814	MedChemExpress	50mg	EUR 439.2

DAPI Dihydrochloride
561706	MedKoo Biosciences	5.0mg	EUR 190

DAPI Dihydrochloride
T19827-10mg	TargetMol Chemicals	10mg	Ask for price
Description: DAPI Dihydrochloride

DAPI Dihydrochloride
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Description: DAPI Dihydrochloride

DAPI Dihydrochloride
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Description: DAPI Dihydrochloride

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Description: DAPI Dihydrochloride

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Description: DAPI Dihydrochloride

DAPI Staining Kit
abx097206-1Kit	Abbexa	1 Kit	EUR 276

FluorLast? with DAPI
1214-20	Biovision	each	EUR 183.6

DAPI Reference Standard
BLI906A-1	Polysciences Europe GmbH	1ml	EUR 265

DAPI Reference Standard
BLI906B-5	Polysciences Europe GmbH	5ml	EUR 522

DAPI Reference Standard
BLI906C-14	Polysciences Europe GmbH	2x7ml	EUR 1007

DAPI Reagent (25μg/mL)
E-CK-A163-100T	Elabscience Biotech	100T	EUR 15

DAPI Reagent (25μg/mL)
E-CK-A163-200T	Elabscience Biotech	200T	EUR 25

DAPI Reagent (25μg/mL)
E-CK-A163-500T	Elabscience Biotech	500T	EUR 55

DAPI Reagent (25μg/mL)
E-CK-A163-50T	Elabscience Biotech	50T	EUR 10

DAPI Solution(1mg/mL)
19178-91	NACALAI TESQUE	1ML	EUR 38.5

DAPI-solution（1mg/ml）
E37F17510DZ	EnoGene	1-mL	EUR 60
Description: Cell-staining.-Nuclear-staining.

DAPI (Molecular Biology Grade)
CE117	GeneOn	5 mg	EUR 72

DAPI (Molecular Biology Grade)
CE118	GeneOn	25 mg	EUR 159.6

DAPI (Molecular Biology Grade)
CE119	GeneOn	100 mg	EUR 382.8

DAPI, 10mg/mL in H2O
40043-1	Biotium	EA	EUR 103

FluorLast? with DAPI and DABCO
1218-20	Biovision	each	EUR 183.6

Fluoromount Mounting Medium with DAPI
42734051-1	Bio-WORLD	20 mL	EUR 76.14

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20004-50mL	AAT Bioquest	50 mL	EUR 109
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OOSB00007-20ML - Dapi-Fluoromount-G
OOSB00007-20ML	Aviva Systems Biology	20mL	EUR 79

DAPI staining kit (ready to use)
EGY0621	EnoGene	10mL	EUR 85

DAPI staining kit (ready to use)
EGY0622	EnoGene	50mL	EUR 185

Annexin V-PE/DAPI Apoptosis Kit
E-CK-A256-100Assays	Elabscience Biotech	100 Assays	EUR 260

Annexin V-PE/DAPI Apoptosis Kit
E-CK-A256-200Assays	Elabscience Biotech	200 Assays	EUR 398

Annexin V-PE/DAPI Apoptosis Kit
E-CK-A256-20Assays	Elabscience Biotech	20 Assays	EUR 75

Annexin V-PE/DAPI Apoptosis Kit
E-CK-A256-50Assays	Elabscience Biotech	50 Assays	EUR 150

Annexin V-APC/DAPI Apoptosis Kit
E-CK-A258-100Assays	Elabscience Biotech	100 Assays	EUR 260

Annexin V-APC/DAPI Apoptosis Kit
E-CK-A258-200Assays	Elabscience Biotech	200 Assays	EUR 398

Annexin V-APC/DAPI Apoptosis Kit
E-CK-A258-20Assays	Elabscience Biotech	20 Assays	EUR 75

Annexin V-APC/DAPI Apoptosis Kit
E-CK-A258-50Assays	Elabscience Biotech	50 Assays	EUR 150

Annexin V-FITC/DAPI Apoptosis Kit
E-CK-A252-100Assays	Elabscience Biotech	100 Assays	EUR 260

Annexin V-FITC/DAPI Apoptosis Kit
E-CK-A252-200Assays	Elabscience Biotech	200 Assays	EUR 398

Annexin V-FITC/DAPI Apoptosis Kit
E-CK-A252-20Assays	Elabscience Biotech	20 Assays	EUR 75

Annexin V-FITC/DAPI Apoptosis Kit
E-CK-A252-50Assays	Elabscience Biotech	50 Assays	EUR 150

Annexin V-EGFP/DAPI Apoptosis Kit
E-CK-A260-100Assays	Elabscience Biotech	100 Assays	EUR 260

Annexin V-EGFP/DAPI Apoptosis Kit
E-CK-A260-200Assays	Elabscience Biotech	200 Assays	EUR 398

Annexin V-EGFP/DAPI Apoptosis Kit
E-CK-A260-20Assays	Elabscience Biotech	20 Assays	EUR 75

Annexin V-EGFP/DAPI Apoptosis Kit
E-CK-A260-50Assays	Elabscience Biotech	50 Assays	EUR 150

Annexin V-AF647/DAPI Apoptosis Kit
E-CK-A254-100Assays	Elabscience Biotech	100 Assays	EUR 260

Annexin V-AF647/DAPI Apoptosis Kit
E-CK-A254-200Assays	Elabscience Biotech	200 Assays	EUR 398

Annexin V-AF647/DAPI Apoptosis Kit
E-CK-A254-20Assays	Elabscience Biotech	20 Assays	EUR 75

Annexin V-AF647/DAPI Apoptosis Kit
E-CK-A254-50Assays	Elabscience Biotech	50 Assays	EUR 150

Annexin V-AF488/DAPI Apoptosis Kit
E-CK-A278-100Assays	Elabscience Biotech	100 Assays	EUR 260

Annexin V-AF488/DAPI Apoptosis Kit
E-CK-A278-200Assays	Elabscience Biotech	200 Assays	EUR 398

Annexin V-AF488/DAPI Apoptosis Kit
E-CK-A278-20Assays	Elabscience Biotech	20 Assays	EUR 75

Annexin V-AF488/DAPI Apoptosis Kit
E-CK-A278-50Assays	Elabscience Biotech	50 Assays	EUR 150

Annexin V-ER780/DAPI Apoptosis Kit
E-CK-A280-100Assays	Elabscience Biotech	100 Assays	EUR 260

Annexin V-ER780/DAPI Apoptosis Kit
E-CK-A280-200Assays	Elabscience Biotech	200 Assays	EUR 398

Annexin V-ER780/DAPI Apoptosis Kit
E-CK-A280-20Assays	Elabscience Biotech	20 Assays	EUR 75

Annexin V-ER780/DAPI Apoptosis Kit
E-CK-A280-50Assays	Elabscience Biotech	50 Assays	EUR 150

Anti-Fade Mounting Medium (With DAPI)
abx090690-10ml	Abbexa	10 ml	EUR 243.6

DAPI blue fluorescent nuclear DNA dye
6244	Immunochemistry	10 mg	EUR 120.5

DAPI in Fluorguard™ (0.3 µg/ml)
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DAPI in Fluorguard™ (1 µg/ml)
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EverBrite™ Mounting Medium with DAPI
23002-1	Biotium	EA	EUR 172

Annexin V-Cyanine5/DAPI Apoptosis Kit
E-CK-A262-100Assays	Elabscience Biotech	100 Assays	EUR 260

Annexin V-Cyanine5/DAPI Apoptosis Kit
E-CK-A262-200Assays	Elabscience Biotech	200 Assays	EUR 398

Annexin V-Cyanine5/DAPI Apoptosis Kit
E-CK-A262-20Assays	Elabscience Biotech	20 Assays	EUR 75

Annexin V-Cyanine5/DAPI Apoptosis Kit
E-CK-A262-50Assays	Elabscience Biotech	50 Assays	EUR 150

FluoroQuest™ Mounting Medium with DAPI
20004	AAT Bioquest	50 mL	EUR 109

Annexin V-PE/TR/DAPI Apoptosis Kit
E-CK-A272-100Assays	Elabscience Biotech	100 Assays	EUR 260

Annexin V-PE/TR/DAPI Apoptosis Kit
E-CK-A272-200Assays	Elabscience Biotech	200 Assays	EUR 398

Annexin V-PE/TR/DAPI Apoptosis Kit
E-CK-A272-20Assays	Elabscience Biotech	20 Assays	EUR 75

Annexin V-PE/TR/DAPI Apoptosis Kit
E-CK-A272-50Assays	Elabscience Biotech	50 Assays	EUR 150

Annexin V-PE/Cyanine5/DAPI Apoptosis Kit
E-CK-A264-100Assays	Elabscience Biotech	100 Assays	EUR 260

Annexin V-PE/Cyanine5/DAPI Apoptosis Kit
E-CK-A264-200Assays	Elabscience Biotech	200 Assays	EUR 398

Annexin V-PE/Cyanine5/DAPI Apoptosis Kit
E-CK-A264-20Assays	Elabscience Biotech	20 Assays	EUR 75

Annexin V-PE/Cyanine5/DAPI Apoptosis Kit
E-CK-A264-50Assays	Elabscience Biotech	50 Assays	EUR 150

Annexin V-PE/Cyanine5.5/DAPI Apoptosis Kit
E-CK-A266-100Assays	Elabscience Biotech	100 Assays	EUR 260

Annexin V-PE/Cyanine5.5/DAPI Apoptosis Kit
E-CK-A266-200Assays	Elabscience Biotech	200 Assays	EUR 398

Annexin V-PE/Cyanine5.5/DAPI Apoptosis Kit
E-CK-A266-20Assays	Elabscience Biotech	20 Assays	EUR 75

Annexin V-PE/Cyanine5.5/DAPI Apoptosis Kit
E-CK-A266-50Assays	Elabscience Biotech	50 Assays	EUR 150

Annexin V-PE/Cyanine7/DAPI Apoptosis Kit
E-CK-A268-100Assays	Elabscience Biotech	100 Assays	EUR 260

Annexin V-PE/Cyanine7/DAPI Apoptosis Kit
E-CK-A268-200Assays	Elabscience Biotech	200 Assays	EUR 398

Annexin V-PE/Cyanine7/DAPI Apoptosis Kit
E-CK-A268-20Assays	Elabscience Biotech	20 Assays	EUR 75

Annexin V-PE/Cyanine7/DAPI Apoptosis Kit
E-CK-A268-50Assays	Elabscience Biotech	50 Assays	EUR 150

Annexin V-APC/Cyanine7/DAPI Apoptosis Kit
E-CK-A270-100Assays	Elabscience Biotech	100 Assays	EUR 260

Annexin V-APC/Cyanine7/DAPI Apoptosis Kit
E-CK-A270-200Assays	Elabscience Biotech	200 Assays	EUR 398

Annexin V-APC/Cyanine7/DAPI Apoptosis Kit
E-CK-A270-20Assays	Elabscience Biotech	20 Assays	EUR 75

Annexin V-APC/Cyanine7/DAPI Apoptosis Kit
E-CK-A270-50Assays	Elabscience Biotech	50 Assays	EUR 150

Fluorescent Mounting Medium with DAPI, 18 ml
E19-18	IHC World	-	EUR 125

EverBrite™ Hardset Mounting Medium with DAPI
23004-1	Biotium	EA	EUR 194

FluoroQuestâ„¢ Anti-fading Mounting Medium with DAPI
20005-20mL	AAT Bioquest	20 mL	EUR 211
Description: FluoroQuest™ with DAPI is an aqueous mounting medium for preserving fluorescence of tissue and cell smears.

DAPI (4',6-Diamidino-2-Phenylindole, Dihydrochloride)
B551	ABM	0.2 ml	EUR 129.6

DAPI-[4',6-Diamidino-2-phenylindole,-dihydrochloride]
E37F17510	EnoGene	10-mg	EUR 260
Description: Cell-staining.-Nuclear-staining.

Anti-fluorescence quenching sealing Kit (including DAPI)
EGY073	EnoGene	100T	EUR 60

FluoroQuest™ Anti-fading Mounting Medium with DAPI
20005	AAT Bioquest	20 mL	EUR 211

EverBrite TrueBlack® Hardset Mounting Medium with DAPI
23018-1	Biotium	EA	EUR 327

EverBrite TrueBlack® Hardset Mounting Medium with DAPI
23018-T-1	Biotium	EA	EUR 88

EverBrite TrueBlack® Hardset Mounting Medium with DAPI
23018-T	Biotium	1ML	EUR 88
Description: N/A

SuperKine™ Enhanced Antifade Mounting Medium with DAPI
BMU107-EN-10mL	Abbkine	10 mL	EUR 39
Description: SuperKine™ Enhanced Antifade Mounting Medium with DAPI is compatible with a wide range of fluorescent dyes and protects the entire visible and infrared spectrum from fluorescence signal quenching.

SuperKine™ Enhanced Antifade Mounting Medium with DAPI
BMU107-EN-50mL	Abbkine	50 mL	EUR 69
Description: SuperKine™ Enhanced Antifade Mounting Medium with DAPI is compatible with a wide range of fluorescent dyes and protects the entire visible and infrared spectrum from fluorescence signal quenching.

DAPI, dilactate (4’, 6-diamidino-2-phenylindole, dilactate)
40009-1	Biotium	EA	EUR 123

4’,6-Diamidino-2-phenylindole dihydrochloride (DAPI)
09224-10	Polysciences Europe GmbH	10mg	EUR 129
Description: 28718-90-3

4’,6-Diamidino-2-phenylindole dihydrochloride (DAPI)
09224-50	Polysciences Europe GmbH	50mg	EUR 494
Description: 28718-90-3

Drop-n-Stain EverBrite™ Mounting Medium with DAPI
23009-1	Biotium	EA	EUR 178

Drop-n-Stain EverBrite™ Mounting Medium with DAPI
23009-T-1	Biotium	EA	EUR 45

Drop-n-Stain EverBrite™ Mounting Medium with DAPI
23009-T	Biotium	1ML	EUR 45
Description: N/A

IHC-Tek DAPI Counterstain Solution, Ready To Use, 50 ml
IW-1404	IHC World	-	EUR 65

Fluoro-KEEPER Antifade Reagent, Non-Hardening Type with DAPI
12745-74	NACALAI TESQUE	2X5ML	EUR 133

DAPI [4,6-Diamidino-2-phenylindole, dihydrochloride] *CAS 28718-90-3*
17510	AAT Bioquest	10 mg	EUR 86

DAPI [4,6-Diamidino-2-phenylindole, dihydrochloride] *CAS 28718-90-3*
17511	AAT Bioquest	100 mg	EUR 222

DAPI [4,6-Diamidino-2-phenylindole, dihydrochloride] *CAS 28718-90-3*
17513	AAT Bioquest	25 mg	EUR 109

DAPI [4,6-Diamidino-2-phenylindole, dihydrochloride] *CAS 28718-90-3*
17510-10mg	AAT Bioquest	10 mg	EUR 86
Description: DAPI is a fluorescent stain that binds strongly to DNA.

DAPI [4,6-Diamidino-2-phenylindole, dihydrochloride] *CAS 28718-90-3*
17511-100mg	AAT Bioquest	100 mg	EUR 222
Description: DAPI is a fluorescent stain that binds strongly to DNA.

DAPI [4,6-Diamidino-2-phenylindole, dihydrochloride] *CAS 28718-90-3*
17513-25mg	AAT Bioquest	25 mg	EUR 109
Description: DAPI is a fluorescent stain that binds strongly to DNA.

Human 4’,6-Diamidino-2-phenylindole dihydrochloride（DAPI)ELISA kit
QY-E05538	Qayee Biotechnology	96T	EUR 433.2

DAPI [4,6-Diamidino-2-phenylindole, dihydrochloride] *10 mM solution in water*
17507	AAT Bioquest	2 mL	EUR 86

DAPI [4,6-Diamidino-2-phenylindole, dihydrochloride] *10 mM solution in water*
17507-2mL	AAT Bioquest	2 mL	EUR 86
Description: DAPI is a fluorescent stain that binds strongly to DNA.

Anti-fluorescence quenching sealing agent (Ready to use，DABCO, including DAPI)
EGY078	EnoGene	100T	EUR 60

DAPI (4',6-Diamidino-2-Phenylindole, Dihydrochloride) for nucleic acid staining
AR1176	BosterBio	10mL(100 assys)	EUR 78

DAPI (4',6-Diamidino-2-Phenylindole, Dihydrochloride) for nucleic acid staining
AR1177	BosterBio	50mL(500 assys)	EUR 121.2

Br-DAPI
T39967-10mg	TargetMol Chemicals	10mg	Ask for price
Description: Br-DAPI

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T39967-1g	TargetMol Chemicals	1g	Ask for price
Description: Br-DAPI

Br-DAPI
T39967-1mg	TargetMol Chemicals	1mg	Ask for price
Description: Br-DAPI

Br-DAPI
T39967-50mg	TargetMol Chemicals	50mg	Ask for price
Description: Br-DAPI

Br-DAPI
T39967-5mg	TargetMol Chemicals	5mg	Ask for price
Description: Br-DAPI

UV Transilluminator 21 x 21cm Dual Wave 254/365nm
ULT4506	Scientific Laboratory Supplies	EACH	EUR 1291.2

UV Transilluminator 21 x 21cm Dual Wave 254/312nm
ULT4508	Scientific Laboratory Supplies	EACH	EUR 1291.2

UV Transilluminator 21 x 26cm Dual Wave 254/365nm
ULT4516	Scientific Laboratory Supplies	EACH	EUR 1752.12

WAVE1 Antibody
44433-100ul	SAB	100ul	EUR 302.4

WAVE1 Antibody
44433-50ul	SAB	50ul	EUR 224.4

WAVE4 Antibody
44434-100ul	SAB	100ul	EUR 302.4

WAVE4 Antibody
44434-50ul	SAB	50ul	EUR 224.4

WAVE4 Antibody
20-abx322912	Abbexa	EUR 376.80 EUR 292.80	100 ug 50 ug

WAVE1 Cell ELISA Kit
abx595627-96tests	Abbexa	96 tests	EUR 764.4

WAVE1 antibody
70R-35533	Fitzgerald	100 ug	EUR 392.4
Description: Purified Rabbit polyclonal WAVE1 antibody

WAVE1 Antibody
ABD13323	Lifescience Market	100 ug	EUR 525.6

WAVE1 Antibody
ABF9229	Lifescience Market	100 ug	EUR 525.6

WAVE4 Antibody
ABF9230	Lifescience Market	100 ug	EUR 525.6

WAVE4 Antibody
1-CSB-PA050047	Cusabio	EUR 266.40 EUR 234.00	100ug 50ug
Description: A polyclonal antibody against WAVE4. Recognizes WAVE4 from Human. This antibody is Unconjugated. Tested in the following application: IHC, ELISA;IHC:1/100-1/300.ELISA:1/10000