The most common malignant neoplasms of the head and neck is laryngeal cancer which presents a significant international health issue.
The purpose of this study to screen potential protein associated with cancer of the larynx with network analysis for further understanding disease pathogenesis and biomarker discovery. differently expressed proteins were extracted from the literature that compare laryngeal cancer patient tissue proteome profiling> s with healthy controls.
PPI network were analyzed for up and down proteins regulated by Cytoscape Version 3.4. After construction of the PPI, topological properties of the two networks has been analyzed. In addition, by using MCODE. Gene Ontology (GO) analysis, related modules and pathways examined. Our study screened 275 proteins differentially change, including 136 up and 139 down-regulated proteins. For each network, has been regarded as the hub of key proteins 20 and 20 as an obstacle.
A total of 26 nodes hub-barriers are introduced to two networks. A total of 11 modules including 6 downregulated and upregulated network module 5 is obtained. GO most significant function within the module is significantly upregulated RNA processing, and most significantly downregulated in the module with the highest score is the respiratory electron transport chain. Among 275 investigated protein, 12 essential proteins determined that 4 of them can be introduced as a biomarker panel that may include YWHAZ, PPP2R1A, HSP90AA1, and CALM3 for human laryngeal cancer.
Ultraviolet wavelength-sensitive opsin Polyclonal Antibody |
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| MBS9233874-01mL | MyBiosource | 0.1mL | EUR 415 |
Ultraviolet wavelength-sensitive opsin Polyclonal Antibody |
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| MBS9233874-5x01mL | MyBiosource | 5x0.1mL | EUR 1841 |
AgileReader TM any filters wavelength from 340nm to 900nm can be customized |
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| AMPR-900-filter | Avans Biotechnology Corp | each | Ask for price |
Orion AQUAfast IV Colorimeter 4 wavelengths and auto ID - EACH |
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| AQ4000 | Scientific Laboratory Supplies | EACH | EUR 2026.35 |
Orion AQUAfast Colorimeter 6 wavelengths for COD and other digestion methods - EACH |
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| AQ3700 | Scientific Laboratory Supplies | EACH | EUR 2373.3 |
DAPI |
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| abx082063-10mg | Abbexa | 10 mg | EUR 276 |
DAPI |
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| 40011-1 | Biotium | EA | EUR 122 |
DAPI |
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| BMD0063-100mg | Abbkine | 100 mg | EUR 849 |
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Description: DAPI is a popular blue fluorescent DNA dye. |
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DAPI |
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| BMD0063-10mg | Abbkine | 10 mg | EUR 119 |
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Description: DAPI is a popular blue fluorescent DNA dye. |
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DAPI |
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| B1098-25 | Biovision | each | EUR 496.8 |
DAPI |
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| B1098-5 | Biovision | each | EUR 170.4 |
DAPI |
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| abx283157-100g | Abbexa | 100 µg | Ask for price |
DAPI |
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| abx283157-20g | Abbexa | 20 µg | EUR 106.25 |
DAPI |
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| abx283157-50g | Abbexa | 50 µg | EUR 237.5 |
DAPI |
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| abx082063-100l | Abbexa | 100 µl | EUR 212.5 |
DAPI |
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| abx082063-1ml | Abbexa | 1 ml | Ask for price |
DAPI |
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| abx082063-200l | Abbexa | 200 µl | Ask for price |
DAPI |
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| BMD0063-each | Abbkine | each | Ask for price |
DAPI |
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| MBS9719177-100mg | MyBiosource | 100mg | EUR 605 |
DAPI |
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| MBS9719177-10mg | MyBiosource | 10mg | EUR 155 |
DAPI |
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| MBS9719177-5x100mg | MyBiosource | 5x100mg | EUR 2685 |
DAPI Reagent |
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| MBS2567122-100Tests | MyBiosource | 100Tests | EUR 85 |
DAPI Reagent |
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| MBS2567122-200Tests | MyBiosource | 200Tests | EUR 95 |
DAPI Reagent |
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| MBS2567122-500Tests | MyBiosource | 500Tests | EUR 115 |
DAPI Reagent |
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| MBS2567122-50Tests | MyBiosource | 50Tests | EUR 80 |
DAPI Reagent |
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| MBS2567122-5x500Tests | MyBiosource | 5x500Tests | EUR 510 |
DAPI Reagent |
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| MBS2563514-10mL | MyBiosource | 10mL | EUR 100 |
DAPI Reagent |
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| MBS2563514-50mL | MyBiosource | 50mL | EUR 150 |
DAPI Reagent |
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| MBS2563514-5mL | MyBiosource | 5mL | EUR 90 |
DAPI Reagent |
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| MBS2563514-5x50mL | MyBiosource | 5x50mL | EUR 640 |
DAPI Dilactate |
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| 17509 | AAT Bioquest | 25 mg | EUR 112 |
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Description: DAPI is a fluorescent stain that binds strongly to DNA. |
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DAPI Dilactate |
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| 17509-25mg | AAT Bioquest | 25 mg | EUR 109 |
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Description: DAPI is a fluorescent stain that binds strongly to DNA. |
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DAPI (hydrochloride) |
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| C3362-10 | ApexBio | 10 mg | EUR 62 |
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Description: A fluorescent probe, commonly used to stain DNA and chromosomes |
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DAPI (hydrochloride) |
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| C3362-25 | ApexBio | 25 mg | EUR 130 |
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Description: A fluorescent probe, commonly used to stain DNA and chromosomes |
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DAPI (hydrochloride) |
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| C3362-5 | ApexBio | 5 mg | EUR 37 |
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Description: A fluorescent probe, commonly used to stain DNA and chromosomes |
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DAPI (Hydrochloride) |
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| MBS696332-25mg | MyBiosource | 25mg | EUR 260 |
DAPI (Hydrochloride) |
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| MBS696332-5mg | MyBiosource | 5mg | EUR 150 |
DAPI (Hydrochloride) |
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| MBS696332-5x25mg | MyBiosource | 5x25mg | EUR 1120 |
DAPI Dihydrochloride |
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| 561706 | MedKoo Biosciences | 5.0mg | EUR 190 |
DAPI dihydrochloride |
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| MB097-10MG | EWC Diagnostics | 1 unit | EUR 41.98 |
|
Description: DAPI dihydrochloride |
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DAPI dihydrochloride |
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| MB097-25MG | EWC Diagnostics | 1 unit | EUR 83.31 |
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Description: DAPI dihydrochloride |
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DAPI dihydrochloride |
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| RM5773-25MG | EWC Diagnostics | 1 unit | EUR 119.85 |
|
Description: DAPI dihydrochloride |
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DAPI (dihydrochloride) |
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| HY-D0814 | MedChemExpress | 50mg | EUR 439.2 |
DAPI Dihydrochloride |
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| T19827-10mg | TargetMol Chemicals | 10mg | Ask for price |
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Description: DAPI Dihydrochloride |
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DAPI Dihydrochloride |
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| T19827-1g | TargetMol Chemicals | 1g | Ask for price |
|
Description: DAPI Dihydrochloride |
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DAPI Dihydrochloride |
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| T19827-1mg | TargetMol Chemicals | 1mg | Ask for price |
|
Description: DAPI Dihydrochloride |
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DAPI Dihydrochloride |
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| T19827-50mg | TargetMol Chemicals | 50mg | Ask for price |
|
Description: DAPI Dihydrochloride |
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DAPI Dihydrochloride |
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| T19827-5mg | TargetMol Chemicals | 5mg | Ask for price |
|
Description: DAPI Dihydrochloride |
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DAPI Dihydrochloride |
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| MBS5756233-100mg | MyBiosource | 100mg | EUR 390 |
DAPI Dihydrochloride |
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| MBS5756233-10mg | MyBiosource | 10mg | EUR 165 |
DAPI Dihydrochloride |
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| MBS5756233-25mg | MyBiosource | 25mg | EUR 225 |
DAPI Dihydrochloride |
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| MBS5756233-50mg | MyBiosource | 50mg | EUR 315 |
DAPI Dihydrochloride |
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| MBS5756233-5mg | MyBiosource | 5mg | EUR 155 |
DAPI Staining Kit |
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| abx097206-1Kit | Abbexa | 1 Kit | EUR 276 |
DAPI Staining Kit |
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| abx097206-100l | Abbexa | 100 µl | EUR 162.5 |
DAPI Staining Kit |
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| abx097206-1ml | Abbexa | 1 ml | Ask for price |
DAPI Staining Kit |
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| abx097206-200l | Abbexa | 200 µl | Ask for price |
DAPI Staining Kit |
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| MBS826728-01mL | MyBiosource | 0.1mL | EUR 140 |
DAPI Staining Kit |
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| MBS826728-5x01mL | MyBiosource | 5x0.1mL | EUR 550 |
DAPI solution（0.25mM） |
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| E37F17510-50-mL | EnoGene | 50 mL | EUR 153 |
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Description: Cell staining. Nuclear staining. |
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DAPI solution（0.25mM） |
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| E37F17510-5x10-mL | EnoGene | 5×10 mL | EUR 173 |
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Description: Cell staining. Nuclear staining. |
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FluorLast? with DAPI |
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| 1214-20 | Biovision | each | EUR 183.6 |
Dapi-Fluoromount-G |
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| MBS679125-20mL | MyBiosource | 20mL | EUR 150 |
Dapi-Fluoromount-G |
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| MBS679125-5x20mL | MyBiosource | 5x20mL | EUR 535 |
DAPI Staining Solution |
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| MBS176580-10mL | MyBiosource | 10mL | EUR 115 |
DAPI Staining Solution |
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| MBS176580-50mL | MyBiosource | 50mL | EUR 135 |
DAPI Staining Solution |
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| MBS176580-5x50mL | MyBiosource | 5x50mL | EUR 450 |
DAPI Reference Standard |
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| BLI906A-1 | Polysciences Europe GmbH | 1ml | EUR 265 |
DAPI Reference Standard |
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| BLI906B-5 | Polysciences Europe GmbH | 5ml | EUR 522 |
DAPI Reference Standard |
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| BLI906C-14 | Polysciences Europe GmbH | 2x7ml | EUR 1007 |
DAPI Reagent (25μg/mL) |
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| E-CK-A163-100T | Elabscience Biotech | 100T | EUR 15 |
DAPI Reagent (25μg/mL) |
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| E-CK-A163-200T | Elabscience Biotech | 200T | EUR 25 |
DAPI Reagent (25μg/mL) |
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| E-CK-A163-500T | Elabscience Biotech | 500T | EUR 55 |
DAPI Reagent (25μg/mL) |
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| E-CK-A163-50T | Elabscience Biotech | 50T | EUR 10 |
DAPI Solution(1mg/mL) |
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| 19178-91 | NACALAI TESQUE | 1ML | EUR 38.5 |
DAPI Led Filter Cube |
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| LBI10101 | Westburg | each | EUR 2735.9 |
DAPI Reagent (25ug/mL) |
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| E-CK-A163-100Tests | Elabscience Biotech | 100Tests | EUR 15 |
DAPI Reagent (25ug/mL) |
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| E-CK-A163-200Tests | Elabscience Biotech | 200Tests | EUR 25 |
DAPI Reagent (25ug/mL) |
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| E-CK-A163-500Tests | Elabscience Biotech | 500Tests | EUR 55 |
DAPI Reagent (25ug/mL) |
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| E-CK-A163-50Tests | Elabscience Biotech | 50Tests | EUR 10 |
DAPI solution (1mg/ml) |
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| MBS8579913-1mL | MyBiosource | 1mL | EUR 140 |
DAPI solution (1mg/ml) |
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| MBS8579913-5x1mL | MyBiosource | 5x1mL | EUR 570 |
DAPI solution（1mg/ml） |
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| E37F17510DZ-1-mL | EnoGene | 1 mL | EUR 60 |
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Description: Cell staining. Nuclear staining. |
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DAPI-solution（1mg/ml） |
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| E37F17510DZ | EnoGene | 1-mL | EUR 60 |
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Description: Cell-staining.-Nuclear-staining. |
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Fluoroshield™ with DAPI |
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| AR-6501-01 | ImmunoBioscience | 20 ml | EUR 68.05 |
Fluoroshield™ with DAPI |
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| AR-6501-02 | ImmunoBioscience | 100 ml | EUR 247.1 |
Fluoroshield with DAPI & PPD |
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| AR-6513-01 | ImmunoBioscience | 20 ml | EUR 68.05 |
Fluoroshield with DAPI & PPD |
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| AR-6513-02 | ImmunoBioscience | 100 ml | EUR 231 |
DAPI (Molecular Biology Grade) |
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| CE117 | GeneOn | 5 mg | EUR 72 |
DAPI (Molecular Biology Grade) |
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| CE118 | GeneOn | 25 mg | EUR 159.6 |
DAPI (Molecular Biology Grade) |
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| CE119 | GeneOn | 100 mg | EUR 382.8 |
Fluoroshield with DAPI & DABCO |
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| AR-6505-01 | ImmunoBioscience | 20 ml | EUR 68.05 |
Fluoroshield with DAPI & DABCO |
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| AR-6505-02 | ImmunoBioscience | 100 ml | EUR 247.1 |
DAPI, 10mg/mL in H2O |
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| 40043-1 | Biotium | EA | EUR 103 |
DAPI Reagent (1 ug/mL) |
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| E-IR-R103-10mL | Elabscience Biotech | 10mL | EUR 35 |
DAPI Reagent (1 ug/mL) |
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| E-IR-R103-50mL | Elabscience Biotech | 50mL | EUR 105 |
DAPI Reagent (1 ug/mL) |
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| E-IR-R103-5mL | Elabscience Biotech | 5mL | EUR 20 |
DAPI Reagent (1 ug/mL) |
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| E-IR-R103-each | Elabscience Biotech | each | Ask for price |
DAPI (Ex375/28, Em460/50) |
|||
| LBI10130 | Westburg | each | EUR 3270 |
Fluoroshield with DAPI & Propylgallate |
|||
| AR-6506-01 | ImmunoBioscience | 20 ml | EUR 68.05 |
Fluoroshield with DAPI & Propylgallate |
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| AR-6506-02 | ImmunoBioscience | 100 ml | EUR 247.1 |
FluorLast? with DAPI and DABCO |
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| 1218-20 | Biovision | each | EUR 183.6 |
Fluoromount Mounting Medium with DAPI |
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| 42734051-1 | Glycomatrix | 20 mL | EUR 76.14 |
FluoroQuestâ„¢ Mounting Medium with DAPI |
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| 20004 | AAT Bioquest | 50 mL | EUR 112 |
|
Description: FluoroQuest™ with DAPI is an aqueous mounting medium for preserving fluorescence of tissue and cell smears. |
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FluoroQuestâ„¢ Mounting Medium with DAPI |
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| 20004-50mL | AAT Bioquest | 50 mL | EUR 109 |
|
Description: FluoroQuest™ with DAPI is an aqueous mounting medium for preserving fluorescence of tissue and cell smears. |
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OOSB00007-20ML - Dapi-Fluoromount-G |
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| OOSB00007-20ML | Aviva Systems Biology | 20mL | EUR 79 |
DAPI staining kit (ready to use) |
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| EGY0621 | EnoGene | 10mL | EUR 85 |
DAPI staining kit (ready to use) |
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| EGY0622 | EnoGene | 50mL | EUR 185 |
DAPI staining kit (ready to use) |
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| MBS8584952-10mL | MyBiosource | 10mL | EUR 200 |
DAPI staining kit (ready to use) |
|||
| MBS8584952-5x10mL | MyBiosource | 5x10mL | EUR 915 |
DAPI staining kit (ready to use) |
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| MBS8584953-50mL | MyBiosource | 50mL | EUR 285 |
DAPI staining kit (ready to use) |
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| MBS8584953-5x50mL | MyBiosource | 5x50mL | EUR 1300 |
Annexin V-PE/DAPI Apoptosis Kit |
|||
| E-CK-A256-100Assays | Elabscience Biotech | 100 Assays | EUR 260 |
Annexin V-PE/DAPI Apoptosis Kit |
|||
| E-CK-A256-200Assays | Elabscience Biotech | 200 Assays | EUR 398 |
Annexin V-PE/DAPI Apoptosis Kit |
|||
| E-CK-A256-20Assays | Elabscience Biotech | 20 Assays | EUR 75 |
Annexin V-PE/DAPI Apoptosis Kit |
|||
| E-CK-A256-50Assays | Elabscience Biotech | 50 Assays | EUR 150 |
Annexin V-APC/DAPI Apoptosis Kit |
|||
| E-CK-A258-100Assays | Elabscience Biotech | 100 Assays | EUR 260 |
Annexin V-APC/DAPI Apoptosis Kit |
|||
| E-CK-A258-200Assays | Elabscience Biotech | 200 Assays | EUR 398 |
Annexin V-APC/DAPI Apoptosis Kit |
|||
| E-CK-A258-20Assays | Elabscience Biotech | 20 Assays | EUR 75 |
Annexin V-APC/DAPI Apoptosis Kit |
|||
| E-CK-A258-50Assays | Elabscience Biotech | 50 Assays | EUR 150 |
Annexin V-FITC/DAPI Apoptosis Kit |
|||
| E-CK-A252-100Assays | Elabscience Biotech | 100 Assays | EUR 260 |
Annexin V-FITC/DAPI Apoptosis Kit |
|||
| E-CK-A252-200Assays | Elabscience Biotech | 200 Assays | EUR 398 |
Annexin V-FITC/DAPI Apoptosis Kit |
|||
| E-CK-A252-20Assays | Elabscience Biotech | 20 Assays | EUR 75 |
Annexin V-FITC/DAPI Apoptosis Kit |
|||
| E-CK-A252-50Assays | Elabscience Biotech | 50 Assays | EUR 150 |
Annexin V-EGFP/DAPI Apoptosis Kit |
|||
| E-CK-A260-100Assays | Elabscience Biotech | 100 Assays | EUR 260 |
Annexin V-EGFP/DAPI Apoptosis Kit |
|||
| E-CK-A260-200Assays | Elabscience Biotech | 200 Assays | EUR 398 |
Annexin V-EGFP/DAPI Apoptosis Kit |
|||
| E-CK-A260-20Assays | Elabscience Biotech | 20 Assays | EUR 75 |
Annexin V-EGFP/DAPI Apoptosis Kit |
|||
| E-CK-A260-50Assays | Elabscience Biotech | 50 Assays | EUR 150 |
Annexin V-AF647/DAPI Apoptosis Kit |
|||
| E-CK-A254-100Assays | Elabscience Biotech | 100 Assays | EUR 260 |
Annexin V-AF647/DAPI Apoptosis Kit |
|||
| E-CK-A254-200Assays | Elabscience Biotech | 200 Assays | EUR 398 |
Annexin V-AF647/DAPI Apoptosis Kit |
|||
| E-CK-A254-20Assays | Elabscience Biotech | 20 Assays | EUR 75 |
Annexin V-AF647/DAPI Apoptosis Kit |
|||
| E-CK-A254-50Assays | Elabscience Biotech | 50 Assays | EUR 150 |
Annexin V-AF488/DAPI Apoptosis Kit |
|||
| E-CK-A278-100Assays | Elabscience Biotech | 100 Assays | EUR 260 |
Annexin V-AF488/DAPI Apoptosis Kit |
|||
| E-CK-A278-200Assays | Elabscience Biotech | 200 Assays | EUR 398 |
Annexin V-AF488/DAPI Apoptosis Kit |
|||
| E-CK-A278-20Assays | Elabscience Biotech | 20 Assays | EUR 75 |
Annexin V-AF488/DAPI Apoptosis Kit |
|||
| E-CK-A278-50Assays | Elabscience Biotech | 50 Assays | EUR 150 |
Annexin V-ER780/DAPI Apoptosis Kit |
|||
| E-CK-A280-100Assays | Elabscience Biotech | 100 Assays | EUR 260 |
Annexin V-ER780/DAPI Apoptosis Kit |
|||
| E-CK-A280-200Assays | Elabscience Biotech | 200 Assays | EUR 398 |
Annexin V-ER780/DAPI Apoptosis Kit |
|||
| E-CK-A280-20Assays | Elabscience Biotech | 20 Assays | EUR 75 |
Annexin V-ER780/DAPI Apoptosis Kit |
|||
| E-CK-A280-50Assays | Elabscience Biotech | 50 Assays | EUR 150 |
Anti-Fade Mounting Medium (With DAPI) |
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| abx090690-10ml | Abbexa | 10 ml | EUR 243.6 |
DAPI blue fluorescent nuclear DNA dye |
|||
| 6244 | Immunochemistry | 10 mg | EUR 120.5 |
Anti-Fade Mounting Medium (With DAPI) |
|||
| abx090690-100l | Abbexa | 100 µl | EUR 137.5 |
Anti-Fade Mounting Medium (With DAPI) |
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| abx090690-1ml | Abbexa | 1 ml | Ask for price |
Anti-Fade Mounting Medium (With DAPI) |
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| abx090690-200l | Abbexa | 200 µl | Ask for price |
Anti-fade Mounting Medium (With DAPI) |
|||
| MBS355738-10mL | MyBiosource | 10mL | EUR 180 |
Anti-fade Mounting Medium (With DAPI) |
|||
| MBS355738-5x10mL | MyBiosource | 5x10mL | EUR 515 |
DAPI blue fluorescent nuclear DNA dye |
|||
| MBS258073-10mg | MyBiosource | 10mg | EUR 245 |
DAPI blue fluorescent nuclear DNA dye |
|||
| MBS258073-5x10mg | MyBiosource | 5x10mg | EUR 930 |
EverBrite™ Mounting Medium with DAPI |
|||
| 23002-1 | Biotium | EA | EUR 172 |