Mechanistically detailed systems biology modeling of the HGF/Met pathway in hepatocellular carcinoma.

Mechanistically detailed systems biology modeling of the HGF/Met pathway in hepatocellular carcinoma.

Hepatocyte progress issue (HGF) signaling by way of its receptor Met has been implicated in hepatocellular carcinoma tumorigenesis and development. Met interplay with integrins is proven to modulate the downstream signaling to Akt and ERK (extracellular-regulated kinase). In this examine, we developed a mechanistically detailed systems biology mannequin of HGF/Met signaling pathway that integrated particular … Read more